AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa
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چکیده
منابع مشابه
Iron-Chelating Drugs Enhance Cone Photoreceptor Survival in a Mouse Model of Retinitis Pigmentosa.
Purpose Retinitis pigmentosa (RP) is a group of hereditary retinal degeneration in which mutations commonly result in the initial phase of rod cell death followed by gradual cone cell death. The mechanisms by which the mutations lead to photoreceptor cell death in RP have not been clearly elucidated. There is currently no effective treatment for RP. The purpose of this work was to explore iron ...
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We have used a color matching technique to estimate the optical density of the foveal cone photopigments in a group of patients with retinitis pigmentosa. We find that foveal cone optical density is reduced in patients with retinitis pigmentosa. This reduction of density can occur early in the disease process and is found in patients with minimal visual field loss or 20/20 visual acuity. Foveal...
متن کاملUnilateral retinitis pigmentosa and cone-rod dystrophy
PURPOSE The purpose of this paper is to report 14 new cases of unilateral retinitis pigmentosa and three new cases of cone-rod dystrophy and to compare the similarities and dissimilarities to those found in the bilateral forms of these disorders. METHODS A total of 272 cases of retinitis pigmentosa and 167 cases of cone-rod dystrophy were studied by corneal full field electroretinograms and e...
متن کاملApoptotic photoreceptor cell death in mouse models of retinitis pigmentosa.
Retinitis pigmentosa (RP) is a group of inherited human diseases in which photoreceptor degeneration leads to visual loss and eventually to blindness. Although mutations in the rhodopsin, peripherin, and cGMP phosphodiesterase genes have been identified in some forms of RP, it remains to be determined whether these mutations lead to photoreceptor cell death through necrotic or apoptotic mechani...
متن کاملmTORC1 sustains vision in retinitis pigmentosa
This work is licensed under a Creative Commons Attribution 3.0 License. "mTORC1 sustains vision in retinitis pigmentosa" (2015).
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ژورنال
عنوان ژورنال: eLife
سال: 2021
ISSN: 2050-084X
DOI: 10.7554/elife.66240